Obesity, a growing epidemic affecting greater than 35% of Americans, is a complex metabolic disease associated with multiple comorbidities and high mortality rate. Management ranges from conservative measures with lifestyle modification to invasive bariatric procedures, depending on a number of factors including prior weight loss success, Body Mass Index (BMI) and underlying comorbidities. More recently non-surgical endoscopic techniques such as the Obalon Balloon system have become an option for patients falling into the obese category and in fact have shown promising results for this patient population.
Non-Invasive Weight Loss Interventions: The Obalon Balloon System
The Obalon Balloon System, a temporary intragastric device, is used to help facilitate weight loss in obese adults with BMIs ranging from 30-40 kg/m2 who have previously failed to lose weight through conservative measures. The system is intended to be used as an adjunct to a moderate intensity diet and behavior modification program with the device removed endoscopically six months after placement. While studies to date have shown the Obalon Balloon System to be a safe and efficacious means of weight loss, the system has proven to be a unique one compared to its weight loss counterparts; requiring less endoscopic procedures with the additional capability of balloon volume titration, ultimately optimizing overall weight loss.
The Microbiome and its Role in Obesity
The gastrointestinal tract is colonized by a vast number of micro-organisms, all of which comprise the microbiota. The microbiome consists of a collection of all the genomic elements of a specific microbiota. Collectively, these microorganisms serve many functions, one of which is gaining increasing attention in the field of medicine; that being its composition and its role in obesity. Variation in intestinal microbiota has been shown to have a strong association in lean individuals while those lacking diversity are linked to adiposity. Animal studies thus far have demonstrated certain phyla to be associated with weight loss versus an obese state, as noted in phyla Bacteroidetes and Firmicutes, respectively. It has been postulated that the means by which bacteria have affected weight lie in the varying effects on energy extraction from one’s diet, ultimately affecting metabolism. The microbiota is a dynamic environment, having the ability to be manipulated by a number of factors including antibiotics, pre and probiotics and diet. However, the extent in which the microbiome plays in overall weight loss success with the use of certain weight loss interventions such as the Obalon balloon system and whether alterations in the microbiome can be observed pre and post intervention remain in question, thus warranting further investigation.
Easy one-click social registrationIs this safe?
We only receive the minimum information necessary to verify your account. We never get access to your friends/contacts or your profile, and we never post on your behalf. Your social account is used for logging in only.ORRegister via email
Send me updates on this Challenge
In order to ensure a fair voting process and to make sure that no one votes more than once, we ask that you register either with a social networking account (easiest, only requires one click) or by registering with your email address (this will require you to click on a verification email that we will send you).
You only need to register once.