Nearly one in five infants with congenital heart disease (CHD) experience perioperative feeding difficulties (1-2). Optimizing nutrition for these infants is important for healing, development, and growth. A healthy gastrointestinal (GI) microbiome promotes nutrition, and thereby growth; however, little is known about how the GI microbiome is altered during the perioperative period in infants with CHD and how these alterations contribute to poor feeding outcomes (3). At the extreme, necrotizing enterocolitis (NEC) occurs in approximately 5-10% of infants perioperatively, contributing to poor feeding outcomes and in-hospital mortality (50-73%) (4-6). Data suggest that preterm infants with NEC have decreased GI microbiome diversity and increased prevalence of pathogenic bacteria that may contribute to this pathology (7). There is currently no data regarding how hypoxia and cardiopulmonary bypass surgery in infants with CHD alters the GI microbiome and contributes to NEC.
Infants with CHD are also at higher risk for perioperative infections with a 13-30% risk of infection postoperative (8-10). The GI microbiome is important for healthy immune function, which is essential in preventing infections (11-14). Data in adults reveal decreased diversity of the GI microbiome after cardiac surgery (15). This study will evaluate the GI microbiome in infants with CHD, identify changes in the microbiome occuring during critical illness before and after cardiopulmonary bypass surgery, and correlate alterations in the GI microbiome with feeding outcomes and infection risks.
Easy one-click social registrationIs this safe?
We only receive the minimum information necessary to verify your account. We never get access to your friends/contacts or your profile, and we never post on your behalf. Your social account is used for logging in only.ORRegister via email
Send me updates on this Challenge
In order to ensure a fair voting process and to make sure that no one votes more than once, we ask that you register either with a social networking account (easiest, only requires one click) or by registering with your email address (this will require you to click on a verification email that we will send you).
You only need to register once.